I’m looking to buy a Samsung 980 pro nvme m.2 and sticking it in an ACASIS enclosure. It should get 2700 MB/s read and write.

I’m wondering if that will be fast enough to boot and run macOS purely from the external drive in a manner that is comfortably fast enough to get normal work (browsing the web, typing word documents, watching YouTube) done.

cfn is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
Check out our Code of Conduct.